Rollins School of Public Health | Faculty Profile
Emory Rollins School of Public Health

Qiang  Zhang

Associate Professor

Faculty, Environmental Health

My research interest is focused on using computer simulations of biological systems to understand and predict the human health effects of environmental perturbations. These perturbations, elicited by environmental chemicals, dietary supplements, and drugs, can alter the dynamics of the molecular circuits and networks operating in cells, leading to multiple disease endpoints. In close collaboration with experimental biologists and toxicologists, I develop mechanistically based computational systems biology models of cellular biochemical and toxicity pathways. These mechanistically-based models will help us to make better predictions of the dose response relationship. The current research focuses on the following areas:

  • Modeling effects of environmental oxidaitive stressors and antioxidants on insulin secretion and sensitivity in diabetes

  • Modeling humoral immune response and its disruption by the environmental contaminant dioxin

  • Modeling the hypothalamic-pituitary-thyroid axis to make health risk predictions for endocrine disrupting chemicals

  • Modeling cellular stress pathways to understand nonlinear dose response and threshold effect of low-level environmental exposure

  • Modeling circadian rhythm of cellular redox state and metabolism

  • Physiologically-based pharmakokinetic (PBPK) or toxicokinetic (PBTK) modeling of tissue dosimetry and chemical exposure

 

Teaching

  • Computational Systems Biology: Modeling Biological Responses (EHS 730/IBS 760R, Fall semester)
  • Introduction to Physiologically-Based Toxicokinetic (PBTK) and Pharmakokinetic (PBPK) Modeling (EH 590R, Spring semester)

Contact Information

1518 Clifton Rd, NE

Atlanta , GA 30322

Phone: 404-727-0154

Email: qiang.zhang@emory.edu

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Areas of Interest

  • Diabetes
  • Risk Assessment
  • Toxicology
  • Disease Pathogenesis
  • Endocrine Disruptors
  • Modeling
  • Exposome
  • Immunology

Education

  • PhD 2003, University of Connecticut
  • MD 1995, Harbin Medical University

Courses Taught

  • EHS 730: Computational Systems Biology

Affiliations & Activities

  • Adjunct faculty in the Molecular and Systems Pharmacology Program of School of Medicine at Emory University
  • Adjunct faculty in the BioEngineering Graduate Program at Georgia Tech

 

Publications