I.     Significant Honors
II.    New Faculty Applointments and Promotions
III.   Achievements in Teaching
IV.   Achievements in Service/Practice
V.    Achievements in Research/Scholarship
       A. Articles Published in Refereed Journals
           Published Abstracts
       B.  Refereed Articles Accepted for Publication During the Academic Year
       C.  Edited or Authored Books Published Druing the Academic Year
       D.  Authored or Edited Books in Press
       E.  Chapters in Press
       F.  Grants, Contracts, or Cooperative Agreements Funded During the Academic Year
       G.  Grants, Contracts or Cooperative Agreements Pending
       H.  Presentation at Professional Meetings
VI.  Narrative
       A.  Contribution to Values Platform of The University
       B.  Strenghts and Weaknesses
       C.  Objectives for 1999-2000

Professor Huiman Barnhart won a travel award from National Science Foundation/American Statistical Association to attend the 52nd session of the International Biometrics Conference in Cape Town, South Africa, December, 1998.

Professor Donna Brogan served on the Institute of Medicine Committee on Lesbian Health Research Priorities.

Professor Donna Brogan gave workshops on sample survey techniques and the use of SUDAAN in Atlanta, GA; College Park, MD; Alexandria, VA; Denver, CO; and Ann Arbor, MI.

Professor M. Elizabeth Halloran gave invited presentations in Cape Town, South Africa; Cuernavaca, Mexico; and the University of Nebraska.

Professor John Hanfelt gave an invited presentation at the Society for Clinical Trials meeting, Anaheim, CA.

Professor Andrzej Kosinski won a travel award from National Science Foundation/American Statistical Association to attend the 52nd session of the International Biometrics Conference in Cape Town, South Africa, December, 1998.

Professor Ira Longini gave invited presentations in Geneva, Switzerland; Donaine de Divonne, France; and Atlanta, GA; and seminars in Cuernavaca, Mexico; and Bangkok, Thailand.

Professor Lance Waller gave invited presentations in Dallas, TX; Dundee, Scotland; Santa Barbara, CA; Atlanta, GA; Le Vesinet, France; and seminars at University of South Carolina; University of Georgia; Emory University (two); and the Environmental Protection Agency Region IV offices.

Mark S. Stevens, MSPH, was selected as The Charles C. Shepard Award winner.   His thesis topic was "An Explatory Analysis of Revictimization and its Effects on Psychological and Social Outcomes in African-American Women".

II.  NEW FACULTY APPOINTMENTS AND PROMOTIONS

M. Elizabeth Halloran, M.D., ScD, M.P.H., was promoted to Professor of Biostatistics, effective September 1998.

Lance Waller, Ph.D., was appointed as Associate Professor of Biostatistics (with tenure), effective August, 1998.

Huiman Barnhart, Ph.D., was promoted to Associate Professor of Biostatistics (with tenure), effective September, 1998.

John Hanfelt, Ph.D., was appointed as Assistant Professor of Biostatistics, effective October, 1998.

Andrzej Kosinski, Ph.D., was recommended for promotion to Associate Professor of Biostatistics (with tenure), effective September, 1999.

Robert Lyles, Ph.D., was appointed as Assistant Professor of Biostatistics, effective January, 1999.

Kristie Polk, M.S., was appointed as Associate in Biostatistics, July, 1999.

 III.  ACHIEVEMENTS IN TEACHING

A.  New courses taught and changes in department curriculum.

No new courses were taught in 1998-99.  The faculty developed substantial changes to the first and second year methods courses, which will be implemented in 1999-2000.

B.  Number of graduates from department with MSPH, MPH or Ph.D. degrees during academic year.
  MSPH - 2  Ph.D. - 1

IV.  ACHIEVEMENTS IN SERVICE/PRACTICE

Professor Huiman Barnhart, PhD., was promoted to Associate Professor of Biostatistics (with tenure), effective September, 1998.

Professor Huiman Barnhart served on the RSPH Transcultural Experience Committee.

Professor Huiman Barnhart chaired the BIOS Computing Committee.

Professor Huiman Barnhart served on the ad hoc BIOS Biostatistical Consulting Center Committee.

Professor Huiman Barnhart chaired the BIOS Qualifying Exam Committee.

Professor Huiman Barnhart served on the RSPH Computing Advisory Committee.

Professor Huiman Barnhart served as a referee for Annals of Statistics.

Professor Huiman Barnhart served on the Invited Speaker Committee for the 1999 CDC/ATSDR Statistical Symposium.

Professor Huiman Barnhart served as Seminar Chair for BIOS, fall semester.

Professor Huiman Barnhart organized an invited session at the Joint Statistical Meetings.

Professor Donna Brogan served as a member of the Institute of Medicine Committee on Lesbian Health Research Priorities.

Professor Donna Brogan served as a consultant to Prudential Center for Health Care Research on design and analysis of sample surveys on consumer satisfaction and health care utilization.

Professor Donna Brogan served as a sample survey consultant to American Cancer Society on two national surveys (incidence and prevalence) on quality of life of cancer survivors.

Associate Lisa Elon served on the BIOS Admissions Committee.

Professor Michael Haber served as BIOS Director of Graduate Studies.

Professor Michael Haber chaired the BIOS Student Recruitment Committee.

Professor Michael Haber chaired on the BIOS Admissions Committee.

Professor Michael Haber served on the ad hoc BIOS Biostatistical Consulting Center Committee.

Professor Michael Haber served on the RSPH Admissions Committee.

Professor Michael Haber served on the University Research Committee.

Professor Michael Haber refereed papers for The American Statistician, Statistics in Medicine, Biometrical Journal, and Psychological Methods.

Professor M. Elizabeth Halloran, MD, ScD, MPH, was promoted to Professor of Biostatistics (with tenure), effective September, 1999.

Professor M. Elizabeth Halloran served on the BIOS Computing Committee.

Professor M. Elizabeth Halloran served on the RSPH Appointment, Promotion, and Tenure Committee.

Professor M. Elizabeth Halloran served as the director of the NIH training program in BIOS.

Professor M. Elizabeth Halloran chaired the NIH Special Study Section for Statistics, February, 1999.

Professor M. Elizabeth Halloran served as Associate Editor, Journal of the American Statistical Association.

Professor M. Elizabeth Halloran served on the editorial board of Statistics in Medicine.

Professor M. Elizabeth Halloran served on the Data Safety and Monitoring Board, Vaxgen International and Domestic HIV Vaccine Trials, Thailand and USA.

Professor M. Elizabeth Halloran advised Aviron on influenza vaccine community trials.

Professor M. Elizabeth Halloran was appointed to the Board of Trustees, National Institute of Statistical Sciences.

Professor M. Elizabeth Halloran served on the Executive Committee that formed the new Vaccine Dinner Club (VDC).

Professor M. Elizabeth Halloran is also meeting with people to form the Center for Disease Ecology under Leslie Real's direction.

Professor John Hanfelt served on the BIOS Qualifying Exam Committee.

Professor John Hanfelt served on the RSPH Shepard Award Committee.

Professor John Hanfelt served as Representative, Atlanta Chapter of the American Statistical Association.

Professor John Hanfelt refereed manuscripts for Biometrics, Journal of the Royal Statistical Society (B), and Statistics in Medicine.

Professor Vicki Hertzberg served on the RSPH Curriculum Committee.

Professor Vicki Hertzberg chaired the GSAS Executive Council.

Professor Vicki Hertzberg served on the General Clinical Research Center (GCRC) Advisory Committee.

Professor Vicki Hertzberg served on the university’s Electronic Research Administration Planning Committee.

Professor Hertzberg served on the Emory University Faculty Council.

Professor Vicki Hertzberg served on the National Institute of Neurological Disorders and Stroke’s Neurosciences Review Committee-A.

Professor Vicki Hertzberg served as Secretary-Treasurer for the Committee of Presidents of Statistical Societies.

Professor Vicki Hertzberg was appointed to the Board of Trustees, National Institute of Statistical Sciences.

Professor Vicki Hertzberg refereed manuscripts for Environmental Health Perspectives.

Professor Andrzej Kosinski served on the BIOS Admissions Committee.

Professor Andrzej Kosinski represented BIOS on the RSPH Faculty Senate.

Professor Andrzej Kosinski was a member of the Review Panel for the Early Detection Research Network: Biomarkers Developmental Laboratories, National Cancer Institute.

Professor Ira Longini chaired the BIOS Curriculum Committee.

Professor Ira Longini served on the BIOS Qualifying Examination Committee.

Professor Ira Longini served on the BIOS Technical Reports committee.

Professor Ira Longini served on the Data Safety and Monitory Committee for a trial of killed enterotoxigenic E. coli vaccine for children in Egypt. The trial is in rural villages near Alexandria.

Professors Ira Longini and M. Elizabeth Halloran are collaborating with investigators in Thailand, the CDC, and VaxGen on design and analysis issues for the first international phase III HIV vaccine trial in Bangkok, Thailand.

Professors Ira Longini and M. Elizabeth Halloran are collaborating with investigators at Baylor College of Medicine and Aviron on the design and analysis of a community trial of live attenuated influenza vaccine.  This trial will evaluate the community-wide impact of mass vaccination of school children.

Professor Robert Lyles served on the BIOS Student Affairs Committee.

Professor Robert Lyles refereed manuscripts for Psychometrika and Annals of Occupational Hygiene.

Senior Associate Michael Lynn served on the BIOS Qualifying Examination Committee.

Senior Associate Michael Lynn served on the BIOS Curriculum Committee.

Senior Associate Michael Lynn served on the BIOS Computer Committee.

Senior Associate Michael Lynn co-chaired the ad hoc BIOS Biostatistical Consulting Center Committee.

Senior Associate Michael Lynn served on the EPID Qualifying Exam Committee.

Senior Associate Michael Lynn served on the Winship Cancer Center Clinical Research Review Committee.

Senior Associate Michael Lynn served on the 1999 Local Arrangements Committee for the ENAR Spring Statistics Meetings in Atlanta.

Senior Associate Michael Lynn served on the National Eye Institute Special Emphasis Panel.

Senior Associate Michael Lynn served on the editorial board for Journal of Refractive Surgery.

Senior Associate Michael Lynn refereed manuscripts for Ophthalmology.

Professor Amita Manatunga served on the BIOS Research Faculty Search Committee.

Professor Amita Manatunga served on the BIOS Qualifying Examination Committee.

Professor Amita Manatunga served on the BIOS Recruitment Committee.

Professor Amita Manatunga co-chaired the ad hoc BIOS Biostatistical Consulting Center Committee.

Professor Amita Manatunga served on the RSPH Shepard Award Committee.

Professor Amita Manatunga served on the RSPH Strategic Planning Committee.

Professor Amita Manatunga served on the GCRC Advisory Committee.

Professor Amita Manatunga served as a referee for Biometrics, Lifetime Data Analysis, Methodology and Computing in Applied Probability, and Statistics in Medicine.

Professor Amita Manatunga chaired the 1999 Local Arrangements Committee for the ENAR Spring Statistics Meetings in Atlanta.

Professor Amita Manatunga provided statistical consultation to the following: Dr. Dominique Musselman, EUSOM; Dr. Andrew Miller, EUSOM; Dr. Mark Feinberg, EUSOM; Dr. Harriett Robinson, Yerkes; Dr. Andrew Taylor, EUSOM; and Dr. Erica Frank, EUSOM.

Senior Associate Azhar Nizam served on the BIOS Admissions Committee.

Senior Associate Azhar Nizam served on the RSPH Faculty Senate.

Senior Associate Azhar Nizam served as editor of Public Health Highlights.

Senior Associate Azhar Nizam served as reviewer for Journal of Statistical Education.

Professor Lance Waller served on the BIOS Research Faculty Search Committee.

Professor Lance Waller served on the BIOS Associate Faculty Search Committee.

Professor Lance Waller served on the BIOS Curriculum Committee.

Professor Lance Waller served on the BIOS ad hoc Biostatistics Consulting Center Committee.

Professor Lance Waller served on the editorial board for Statistics in Medicine.

Professor Lance Waller served as Associate Editor for The American Statistician.

Professor Lance Waller served as Newsletter Editor for Section on Statistics and the Environment of the American Statistical Association.

Professor Lance Waller served as reviewer for the draft National Research Council report, “Ozone Forming Potential of Reformulated Gasoline.”

Professor Lance Waller served as referee for Journal of the American Statistical Association; Biometrics; Statistics in Medicine; International Journal of Epidemiology; American Statistician; Emerging Infectious Diseases; Statistica Neerlandica; Annals of the Institute of Statistical Mathematics; Environmental and Ecological Statistics, and Journal of Theoretical Biology.

Senior Associate Rebecca Zhang served on the BIOS Qualifying Exam Committee.

Senior Associate Rebecca Zhang served on the BIOS Recruitment Committee.

V. ACHIEVEMENTS IN RESEARCH/SCHOLARSHIP

A. ARTICLES PUBLISHED IN REFEREED JOURNALS

Barnhart, Huiman X.  A Probit Model for Random Length Ordinal Data.  Communications in Statistics -- Theory and Method,  27(7):1693-1714, 1998.

Barnhart, Huiman X.  AS, Sampson A. “A regression model for multivariate random length data.” Statistics in Medicine, 1999; 18:  (2) 199-211.

Beck AD.  Wilson WR.  Lynch MG.  Lynn MJ.  Noe R. Trabeculectomy with adjunctive mitomycin C in pediatric glaucoma. American Journal of Ophthalmology.  126(5):648-57, 1998 Nov.

Bradley DV.  Fernandes A.  Lynn M.  Tigges M.  Boothe RG.  Emmetropization in the rhesus monkey (Macaca mulatta): birth to young adulthood.  Investigative Ophthalmology & Visual Science.  40(1):214-29, 1999 Jan.

Brinton, LA, Donna R Brogan, RJ Coates, CA Swanson, N Potischman, JL Stanford (1998).  “Breast Cancer Risk among Women Under 55 Years of Age by Joint Effects of Usage of Oral Contraceptives and Hormone Replacement Therapy”, Menopause:The Journal of the North American Menopause Society, 5(3), 145-151.

Chen M-H., Manatunga A.K., Williams C.J.  Heritability Estimates from Human Twin Data by Incorporating Historical Prior Information.  Biometrics 1998, 54, 1348-1362.

Childs, E., Lyles, R.H., Selnes, O.A., Mellors, J., Chen, B., and McArthur, J.C. ?Plasma Viral Load and CD4 Lymphocytes as Predictive Markers for HIV-Associated Dementia and Sensory Neuropathy?, Neurology 52, 607-613 (1999).

Durham, LK, Halloran, ME, Longini, IM, Manatunga, AM (1999) Comparison of two nonparametric methods for exploring time-dependent treatment effects.  Applied Statistics, 48(3):395-407.

Durham LK, Longini Jr. IM, Halloran ME, Clemons JD, Nizam A, Rao M.  Estimation of Vaccine Efficacy in the Presence of Waning: Application to Cholera Vaccines.  Am J Epidemiol 1998; 147: 948-959.

Ellis, M.J., Jenkins, S., Hanfelt, J., Redington, M.E., Taylor, M., Leek, R., Siddle, K. and Harris, A.:  Insulin-like growth factors in human breast cancer.  Breast Cancer Research and Treatment 52:175-184, 1998.

Evans, S.R.T., Nolla, J., Hanfelt, J., Shabahang, M., Nauta, R.J. and Shchepotin, I.B.:  Vitamin D receptor expression as a predictive marker of biological behavior in human colorectal cancer.   Clinical Cancer Research 4:1591-1595, 1998.

Gammon, MD, JB Schoenberg, SL Teitelbaum, LA Brinton, N Potischman, CA Swanson, Donna Brogan, RJ Coates, KE Malone, JL Stanford (1998) “Cigarette Smoking and Breast Cancer Risk among Young Women”, Cancer Causes and Control, 9:6, 583-590.

Gammon, Marilie, JB Schoenberg, JA Britton, JL Kelsey, JL Stanford, KE Malone, RJ Coates, Donna Brogan, N Potischman, CA Swanson, LA Brinton (1998).  "Electric Blanket Use and Breast Cancer Risk among Younger Women", American Journal of Epidemiology, 148(6), 556-63.

Garrard, J., Rolnick, S.J., Nitz, N.M., Luepke, L., Jackson, J., Fischer, L.R., Leibson, C., Bland, P.C., Heinrich, R. and Waller, L.A. (1998)  “Clinical detection of depression among community based elderly people with self reported symptoms of depression”.  Journals of Gerontology Series A: Biological Sciences and Medical Sciences.  53, M92-M101.

Gearing M.  Lynn M.  Mirra SS. Neurofibrillary pathology in Alzheimer Disease with Lewy bodies: two subgroups.  Archives of Neurology.  56(2):203-8, 1999 Feb.

Ghosh, M., Natarajan, K., Waller, L.A., and Kim, D. (1999)  “Hierarchical Bayes GLM's for the analysis of spatial data: an application to disease mapping”.  Journal of Statistical Planning and Inference 75, 305-318.

Golm, G.T., Halloran, M.E. and Longini, I.M.: Semiparametric methods for multiple exposure and a bivariate outcome in HIV vaccine trials.  Biometrics 55, 94 -101 (1999).

Golm, G.T., Halloran, M.E. and Longini, I.M.: Semiparametric models for mismeasured exposure information in vaccine trials.  Statistics in Medicine 17, 2335-2352 (1998).

Haber M., Ndikuyeze, A.  Estimation of individual and population effectiveness of vaccination from time-to-disease Data.  Statistics in Medicine 17, 2617-2623 (1998).

Hanfelt, J.J. and Liang, K. -Y.: Inference for odds ratio regression models with sparse dependent data.  Biometrics 54:136-147, 1998.

Halloran, ME (1998) Statistical issues in HIV vaccine trial design, Journal of the Royal Statistical Society 161:  265-272.

Hoppin JA, Tolbert PE, Flanders WD, Zhang RH, Deniels DS, Ragsdale BD, Brann EA. “Occupational Risk Factors for Sarcoma Subtypes”  Epidemiology, May 1999 Vol. 10, No. 3.

Huether, C.A., Ivanovich, J., Goodwin, B.S., Krivchenia, E.L., Hertzberg, V.S., Edmonds, L.D., May, D.S., Priest, J.H.  Maternal age specific risk rate estimates for Down syndrome among live births in whites and older races from Ohio and Metropolitan Atlanta, 1970-1989.  J Met Genet 35:  482-490, 1998.

Kieszak SM, Flanders WD, Kosinski AS, Shipp CC, Karp H. “A comparison of the Charlson comorbidity index derived from medical record data and administrative billing data.”  Journal of Clinical Epidemiology, 1999; 52: (2) 137-142.

Kosinski AS. “A procedure for the detection of multivariate outliers.”  Computational Statistics and Data Analysis, 1999; 29 (2):145-161.

Kulbaski MJ, Marshall JJ, Kosinski AS, Lumsden AB. “An evaluation of the utility of intravascular ultrasound in an endovascular practice.” Vascular Surgery, 1998; 32:  (6) 535-544.

Kleeberger, C.A., Lyles, R.H., Rinaldo, C.R., Phair, J.P., Margolick, J.B., and Giorgi, J.V. ?Viability and Function of Stored Mononuclear Leukocyte Specimens from a Multicenter Study?An Approach to Quality Assurance?, Clinical and Laboratory Diagnostic Immunology, 6, 14-19 (1999).

Longini, I.M., Hudgens, M.G., Halloran, M.E. and Sagatelian, K.:  A Markov model for measuring vaccine efficacy for both susceptibility to infection and reduction in infectiousness for prophylactic HIV vaccines.  Statistics in Medicine 18, 53-68 (1999).

Lyles, R.H., Chu, C., Mellors, J., Margolick, J., Detels, R., Giorgi, J., Al-Hboul, Q., and Phair, J.P. ?Prognostic Value of HIV RNA in the Natural History of Pneumocystis carinii Pneumonia, Cytomegalovirus, and Mycobacterium avium Complex Disease”, AIDS, 13, 341-350 (1999).

Lyles, R.H. and Kupper, L.L. ?UMVU Estimators for the Population Mean and Variance Based on Random Effects Models for Lognormal Data?, Communications in Statistics-Theory and Methods, 27, 795-818 (1998).

Lyles, R.H. and Xu, J. ?Classifying Individuals Based on Predictors of Random Effects?, Statistics in Medicine, 18, 35-52 (1999).

Lyles, R.H., Muñoz, A., Xu, J, Taylor, J.M.G., and Chmiel, J. ?Adjusting for Measurement Error to Assess Health Effects of Variability in Biomarkers?, Statistics in Medicine, 18, 1069-1086 (1999).

Maibach, Hilda, R Keenlyside, D Fitzmaurice, Donna Brogan, J Essien (1998).  “Future Directions for Research in Laboratory Medicine: Findings of a Delphi Survey of Stakeholders”, Clinical Laboratory Management Review, 12(4), July/August, 221-230.

McLeskey, S.W., Tobias, C.A., Vezza, P.R., Filie, A.F., Kern, F.G. and Hanfelt, J.J.:  Tumor growth of FGF or VEGF transfected MCF-7 breast carcinoma cells correlates with density of specific microvessels independent of the transfected angiogenic factor.  Am. J. Pathology 153:1993-2006, 1998.

Osowski CL.  Dix SP.  Lynn M.  Davidson T.  Cohen L. Miyahara T.  Sexauer MC.  Joyce R.  Yeager A.  Wingard JR. An open-label dose comparison study of ondansetron for the prevention of emesis associated with chemotherapy prior to bone marrow transplantation.  Supportive Care in Cancer.  6(6):511-7, 1998 Nov.

Sacktor, N.C., Lyles, R.H., Skolasky, R.L., Anderson, D.E., McFarlane, G., Miller, E.N., Selnes, O.A., Becker, J.T., Cohen, B., Wesch, J., and McArthur, J.C. ?Combination Antiretroviral Therapy Improves Psychomotor Performance in HIV Seropositive Homosexual Men?, Neurology, 52, 1640-1647 (1999).

Stoller, J.l., A.S. Buist, B. Burrows, R.G. Crystal, R.J.  Fallat, K. McCarthy, M.D. Schluchter, N.T. Soskel, R. Zahang (1998). Alpha 1-Antitrypsin Deficiency Registry Study Group.  "Survival and FEV1 decline in individuals with severe deficiency of a1-antitrypsin".  American J Respir and Critical Care Medicine 1998; 158:  49-59.

Taylor, T., Specker, B., Robbins, J., Sperling, M., Ho, M., Ain, K., Bigos, S.T., Brierley, J., Cooper, D., Haugen, B., Hay, I., Hertzberg, V., Klein, I., Klein, H., Ladenson, P., Nishiyama, R., Ross, D., Sherman, S., Maxon, H.R. Outcome after Treatment of High-Risk Papillary and Non-H?rthle-Cell Follicular Thyroid Carcinoma. Ann Intern Med 129(8):  622-627, 1998.

Troisi R, HA Weiss, RN Hoover, NA Potischman, CA Swanson, Donna Brogan, RJ Coates, MD Gammon, KE Malone, JR Daling, LA Brinton (1998).  "Pregnancy Characteristics and Maternal Risk of Breast Cancer", Epidemiology, 9(6), 641-647.

Waller, L.A., Louis, T.A., and Carlin, B.P. (1999)  “Environmental justice and statistical summaries of differences in exposure distributions”.  Journal of Exposure Analysis and Environmental Epidemiology. 9, 56-65.

Weiss, HA, RA Troisi, MA Rossing, Donna Brogan, RJ Coates, MD Gammon, NA Potischman, CA Swanson, LA Brinton (1998).  "Fertility Problems and Breast Cancer Risk in Young Women: A Case-Control Study", Cancer Causes and Control, 9, 331-9.

Weiss, HA, RA Troisi, MA Rossing, Donna Brogan, RJ Coates, MD Gammon, NA Potischman, D Daniels, D Rolka, F Marsteller, M Chattopadhyay (1998).  "Sample Design to Integrate Two Statewide Random Digit Dialing (RDD) Surveys", in Symposium 97: New Directions in Surveys and Censuses: Proceedings, Statistics Canada, Ottawa, Ontario, 288-291.

Weintraub WS, Culler SD, Kosinski AS, Becker ER, Mahoney EM, Burnette JC, Spertus JA, Feeny D, Cohen DJ, Krumholz H, Ellis SG, Demopoulos L, Robertson D, Boccuzzi SJ, Barr E, Cannon CP. “Economies, health-related quality of life, and cost-effectiveness methods for the TACTICS (treat angina with Aggrastat (R) [tirofiban] and determine cost of therapy with invasive or conservative strategy)-TIMI 18 trial.”  American Journal of Cardiology, 1999; 83 (3): 317-322.

Zhang, L.R., Kharbanda, S., Hanfelt, J. and Kern, F.: Both autocrine and paracrine effects of transfected acidic fibroblast growth factor are involved in the estrogen-independent and antiestrogen-resistant growth of MCF-7 breast cancer cells.  Cancer Research 58:352-361, 1998.

Yang LL.  Lambert SR.  Lynn MJ.  Stulting RD. Long-term results of corneal graft survival in infants and children with Peters Anomaly.  Ophthalmology.  106(4):833-48, 1999 Apr.

Published abstracts:

Gannichida, T, A Ervin, M Gemmill, A Drack, M Lynn. Relationship between clinical symptom report and ophthalmic function in virtual environment with HMD.  Invest Ophthalmol Vis Sci 1998; 39(Suppl).

Gannichida, T, A Ervin, M Gemmill, A Drack, P Holt, M Lynn. Ophthalmic changes associated with symptom reports after use of a head-mounted display.  Invest Ophthalmol Vis Sci 1999; 40(Suppl) S58

Gemmill, M, T  Gannichida, A Ervin, A Drack, P  Holt, M Lynn. Effects of viewing a movie using on pediatric ophthalmic function and symptom report.  Invest Ophthalmol Vis Sci 1998; 39(Suppl)

King SB 3rd, Kosinski AS, Weintraub WS. “Eight year outcome in the Emory Angioplasty vs. Surgery Trial.”  Circulation, 1998; 98 (17): I-197.

Yang, LL, SR Lambert, MG Lynch, MJ Lynn, RD Stulting. Long-term reults of surgical management of glaucoma in infants and children with Peters' Anomaly.  Invest Ophthalmol Vis Sci 1999; 40(Suppl) S268

B.  REFEREED ARTICLES ACCEPTED FOR PUBLICATION DURING THE ACADEMIC YEAR

Alazraki NP, Krawczynska EG, Kosinski AS, DePuey, EG 3rd, Ziffer JA, Taylor T Jr, Pettigrew RI, Vansant JP, Shaw LJ, Weintraub WS, King SB 3rd. “Prognostic value of T1-201 SPECT for Patients with multi vessel Coronary Disease Post-Revascularization: Results from the Emory Angioplasty-Surgery Trial.”  The American Journal of Cardiology, 1999 (accepted).

Albalak, R., Keeler, G.J., Frisancho, A.R., Haber, M.  Assessment of PM10 concentrations from domestic biomass fuel combustion in two rural Bolivian highland villages.  Environmental Sciences and Technology (accepted).

Best, N.G., Arnold, R.A., Thomas, A., Waller, L.A., and Conlon, E.M. (1999, to appear)  “Bayesian models for spatially correlated disease and exposure data”'.  Bayesian Statistics 6, J.M. Bernardo, J.O. Berger, A.P. Dawid, and A.F.M. Smith, eds. Oxford University Press, Oxford.

Coates, RJ, RJ Uhler, HI Hall, N Potischman, LA Brinton, R Ballard-Barbash, MD Gammon, DR Brogan, JR Daling, KE Malone, JB Schoenberg, CA Swanson (in press).  “Risk of Breast Cancer in Young Women in Relation to Body Size and Weight Gain in Adolescence and Early Adulthood”, British Journal of Cancer.

Datta, S., Halloran, M.E. and Longini, I.M.: Randomization by individual or by household in vaccine studies.  Biometrics.  (in print).

Flanders WD, Kosinski AS, Barnhart HX. “An estimated score method for missing and auxiliary covariates in two stage studies.”  Journal of the American Statistical Association, 1999 (under revision).

Frank, Erica, Julia McMurray, Mark Linzer, Lisa Elon??Career satisfaction of US women physicians: results from the Women Physicians? Health Study?. Archives of Internal Medicine.

Frank, Erica, Lisa Elon, Lynne Harvey.  ?Family responsibilities and domestic activities of US women physicians.?. Archives of Family Medicine.

Giselle Corbie-Smith, Erica Frank, Herbert Nickens, Lisa Elon.  ?Prevalence and correlates of ethnically-based harassment in US women physicians?  Academic Medicine

Green, Joanne and Huiman X. Barnhart.  The impact of lesion laterality on neuropsychological  change following posterior pallidotomy: A review of current findings. Brain and Cognition,  1999, in press.

Haber, M.  Estimation of direct and indirect effects of vaccination.  Statistics in Medicine (accepted).

Haber, M.  Estimation of vaccination effectiveness from HIV vaccine trails.  Biometrical Journal (accepted).

Hall, HI, RJ Coates, RJ Uhler, LA Brinton, MD Gammon, Donna Brogan, N Potischman, KE Malone, CA Swanson (in press, accepted Feb. 1999).  “Stage of Breast Cancer in Relation to Body Mass Index and Bra Cup Size”, International J Cancer.

Halloran, M.E., Longini, I.M. and Struchiner, C.J.: Design and interpretation of vaccine field studies.  Epidemiologic Reviews (accepted).

Hanfelt, J.J., Slack, R.S. and Gehan E.A.:  A modified version of Simon's optimal design when the criterion is the median sample size.  Controlled Clinical Trials (to appear).

Hanfelt, J.J.:  Optimal multi-stage designs for a Phase II trial that permits one dose escalation.  Statistics in Medicine (to appear).

Hill, E.G., Allen, A.S., Waller, L.A. (1999, to appear)  “A comparison of focused score tests and Bayesian hierarchical models for detecting spatial disease clustering”.  Journal of the National Institute of Public Health.

Jacquez, G.M. and Waller, L.A (1999, to appear)  “The effect of uncertain locations on disease cluster statistics”.  In Quantifying Spatial Uncertainty in Natural Resources: Theory and Applications for GIS and Remote Sensing, H.T. Mowrer and R.G. Congalton, eds. Arbor Press.

Kemp J, Martinez C, Klyce S, Coorpender S, McDonald M, Lucciano L, Lynn M, Waring G, the PERK Study Group. Diurnal fluctuations in corneal topography 10 years after radial keratotomy in the PERK Study. Cataract and Refractive Surgery.

Kosinski AS, Flanders WD. “Regression model for estimation for odds ratios with misclassified exposure.” Statistics in Medicine, 1999 (in press).

Kosinski AS. “A Procedure for the detection of multiple outliers in linear regression.”  Technometrics, 1999 (under revision).

Kutner, Nancy G.,  Elizabeth F. Mistretta,  Huiman X. Barnhart and Brooke Fielding. Family members’ perceptions of quality of life change in dementia SCU residents.  Journal of Applied Gerontology, 1999, in press.

Lee, S.S., Gerberich, S.G, Waller, L.A., Anderson, A., and McGovern, P. (1999, to appear) “Work-related assault injuries among nurses”.  Epidemiology.

Leibson, C.L., Garrard, J., Nitz, N., Waller, L., Indritz, M., Jackson, J., Rolnick, S.J., and Luepke, L. (1999, to appear)  “The role of depression in the association between self-rated physical health and clinically defined illness”.  The Gerontologist.

Longini, I.M., Hudgens, M.G. and Halloran, M.E.: Estimation of vaccine efficacy for both susceptibility to infection and reduction in infectiousness for prophylactic HIV vaccines with partner augmentation. In The Quantitative Evaluation of HIV Prevention Programs (Eds. Kaplan, E. and Brookmeyer, R.), Yale University Press, New Haven (accepted).

Lyles, R.H. and Kupper, L.L. ?A Note on Confidence Interval Estimation in Measurement Error Adjustment?, The American Statistician (1999, to appear).

Manatunga A.K. and Oakes D.  Parametric Analysis for Matched Pair Data.  (in press – Life Time Data Analysis)

Potischman, N, CA Swanson, RJ Coates, Donna Brogan, J Curtin, LA Brinton (in press). “The Intake of Food Groups and Associated Micronutrients In Relation to Risk of Early Stage Breast Cancer”, International Journal of Cancer.

Salmon, D.A., Haber, M., Gangarosa, E.J., Phillips, L., Smith, N., Chen, R.T.  Health consequences of religious and philosophical exemptions from immunization laws: Individual and social risk of measles.  Journal of the American Medical Association (accepted).

Scanlon, P.D., Connett, J.E., Waller, L.A., Altose, M.D., Bailey, W.C., Buist, A.S., and Tashkin, D.P. (for the Lung Health Study Research Group) (1999, to appear)  “Smoking cessation and lung function in mild-to-moderate COPD: the Lung Health Study.  American Journal of Respiratory and Critical Care Medicine.

Stiger, Thomas R., Huiman X. Barnhart, John M. Williamson. Testing proportionality in the proportional odds model fitted with GEE.  Statistics in Medicine,  1999, in press.

Waller, L.A. and Poquette, C. (1999, to appear)  “The power of focused score tests under mis-specified cluster models”. In Advanced Methods for Disease Mapping and Risk Assessment for Public Health Decision Making, A.B. Lawson, D. Boehning, E. Lesaffre, A. Biggeri, J.-F. Viel and R. Bertollini, eds. John Wiley and Sons, Chinchester.

Weintraub WS, Deaton C, Shaw L, Mahoney E, Morris D, Saunders C, Canup D, Connolly S, Culler S, Becker E, Kosinski AS, Boccuzzi S. “Can Cardiovascular Clinical Characteristics Be Identified and Outcome Models be Developed From an In-Patient Claims Database?”  American Journal of Cardiology, 1999 (in press).

Weiss, Helen, Louise Brinton, Nancy Potischman, Donna Brogan, Ralph Coates, Marilie Gammon, Kathy Malone, Janet Schoenberg (in press, accepted Jan. 1999).  "Breast Cancer Risk in Young Women and History of Selected Medical Conditions", International Journal of Epidemiology.

C. EDITED OR AUTHORED BOOKS PUBLISHED DURING THE ACADEMIC YEAR

Gravina-Taddei CF, Weintraub WS, Shaw L, Kosinski AS.  “Coronary angioplasty and other transcatheter revascularization procedures.” in Wenger NK (Ed.) Cardiovascular Disease in the Octogenarian and Beyond, (Martin Dunitz, London, 1999).

Halloran ME and Geisser, S. Statistics in Genetics, (1999) eds. (IMA volumes in mathematics and its applications; vol.112). Springer Verlag, New York.

D. AUTHORED OR EDITED BOOKS IN PRESS

Curns AT, Nizam A.  Student Solutions Manual for Kleinbaum, Kupper, Muller, Nizam’s Applied Regression Analysis and Other Multivariable Methods.  Brooks/Cole, Pacific Grove (1998).

Halloran ME and Berry, D.  Statistics in Epidemiology, Environmental Health and Clinical Trials, (1999) eds.. (IMA volumes in mathematics and its applications; vol. in press). Springer Verlag, New York.

Halloran, M.E., Longini, I.M. and Struchiner, C.J.: The Design, Analysis and Interpretation of Vaccine Studies. Springer-Verlag (in preparation).

Kleinbaum DG, Kupper LL, Muller KE, Nizam A.  Applied Regression Analysis and Multivariable Methods (3rd Ed.)  Brooks/Cole, Pacific Grove (1998).

Longini, I.M., Hudgens, M.G.:  Lecture Notes on Stochastic Processes in Biostatistics:Applications to Infectious Diseases. Springer-Verlag (in preparation).

E. CHAPTERS IN PRESS

Halloran ME. (1999) Study design and dynamics chapters (2 chapters), in Epidemiologic Methods for Infectious Diseases, ed. Thomas, J., Weber, D., and Weigel, K. Academic Press, (in prep).

Lyles, R.H. and Kupper, L.L. ?Measurement Error Models for Environmental and Occupational Health Applications?, in Handbook of Statistics, Volume on Bio-Environmental and Public Health Statistics, edited by C.R. Rao and P.K. Sen (in press).

F. GRANTS, CONTRACTS, OR COOPERATIVE AGREEMENTS FUNDED DURING ACADEMIC YEAR

PI:  Dr. Marc Chimowitz (EUSOM)
Director, Statistical Coordinating Center:  Vicki Hertzberg
Deputy Director:  Mike Lynn
Statistician: Andrzej S. Kosinski
Title:  Warfarin vs Aspirin for Symptomatic Intracranial Disease (WASID)
Funding Agency:  NINDS/NIH
Direct costs for the year:  $2,059,029
Indirect costs for the year:  $1,085,889

P.I.:  H. Frumkin (EOH)
Statistician:  Vicki Hertzberg
Title: Cohort Study of Former Employees of a Chloraklaki Plant in Brunswick
Funding Agency:  NIH
Direct costs for the year:  $250,366
Indirect costs for the year: $81,579

PI:  Dr. M. Elizabeth Halloran
Investigator:  Ira Longini (BIOS)
Title: R01, Design and Analysis of HIV Vaccine Trials
Funding agency: NIH/NIAID
Direct costs for year: $117,343
Indirect costs for year: $84,692

PI:  Dr. Andrzej Kosinski (BIOS)
Co-Investigator:  Dr. Huiman X. Barnhart
Title: Methods for Evaluating Non-invasive Diagnostic Test
Funding Agency:  AHA
Direct costs for the year:  $103,458
Indirect costs for the year:  $10,346

PI:  Dr. Andrzej Kosinski (BIOS)
Title: Statistical Coordinating Center for the Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Study
Funding Agency:  Rhode Island Hospital/NIH
Direct costs for the year:  $75,877
Indirect costs for the year:  $36,606

PI: Dr. Scott Lambert (EUSOM)
Statistician:  Michael Lynn
Title:  Infant Aphakia Treatment Study (IATS)
Funding Agency:  The National Eye Institute of NIH
Direct costs for the year:  $50,000
Indirect costs for the year:  $27,250

PI:  Dr. Angel Leon (EUSOM)
Co-Investigator:  Dr. Andrzej Kosinski (BIOS)
Title:  Primary Implant of Cardioverter Defibrillators in high-risk ventricular arrhythmia (PRIDE)
Funding Agency:  Cardiac Pacemakers, Inc.
Direct costs for the year:  $155,847
Indirect costs for the year:  $15,584

PI:  Dr. Jerry Vitek (EUSOM)
Statistician:  Dr. Huiman X. Barnhart
Title: Deep Brain Stimulation in Parkinson's Disease. (Randomized Clinical Trial)
Funding Agency:  NINDS
Direct costs for the year:  $560,080
Indirect costs for the year  $301,723

PI:  Dr. Lance A. Waller (BIOS)
Ttle: Statistical Methods to Assess Environmental Justice
Funding Agency:  NIEHS
Direct costs for the year:  $161,492
Indirect costs for the year:  $42,414

PI:  Dr. Lance A. Waller (BIOS)
Title:  Small Area Estimation of Diabetes Prevalence
Funding Agency:  ASPH/CDC
Direct costs for the year:  $68,677
Indirect costs for the year:  $37,429

G. GRANTS, CONTRACTS, OR COOPERATIVE AGREEMENTS PENDING

PI: Dr. Erica Frank
Statistician:  Lisa Elon
Title:  “Medical students” prostate cancer-related characteristics
Funding Agency: Association of Teachers of Preventive Medicine
Direct costs for the year:  $157,350
Indirect costs for the year:  $90,006

PI:  Dr. Howard Frumkin
Statistician:  Lance A. Waller
Title:  Pesticides as Endrocrine Disruptors:  A Study in the Columbian Floriculture Industry
Funding Agency:  Thomas Jefferson University
Direct costs for the year:  $114,998
Indirect costs for the year:  $62,674

PI: Dr. John Hanfelt (BIOS)
Title:  Statistical Methods For Sparse Dependent Data
Agency:  NIH
Direct costs for the year:  $94,466
Indirect costs for the year:  $41,015

PI:  Dr. Reynaldo Martorell, (International Health -RSPH)
Statistician:  Dr. Huiman X. Barnhart
Title: Generational Effects of Malnutrition
Funding Agency:  NICHD
Direct costs for the year:  $300,244
Indirect costs for the year:  $68,325

PI:  Andrew Miller, MD
Statistician:  Amita Manatunga
Title:  IF Nalpha-Induced Depression:  Pathophysiology and Treatment
Funding Agency:  NIMH/NIH
Direct costs for the year:  $203,655
Indirect costs for the year:  $102,817

PI:  Dr. William S. Pearl, MD (EUSOM)
Co-Investigator:  Andrzej Kosinski
Title:  Clinical Prediction Rules for fractures of the face and mandible
Funding Agency: EMCF
Direct costs for the year:  $24,937
Indirect costs for the year:  none

PI:  Dr. Lance A. Waller (BIOS)
Title:  Center of Excellence in Health Statistics:  Center for Public Health Surveillance Research
Funding Agency:  Centers for Disease Control and Prevention
Direct costs for the year:  $236,049
Indirect costs for the year:  $122,755

PI:  Dr. Lance A. Waller (BIOS)
Title:  Spatial Analysis of Epidermal Nerve Fibers
Agency: NIH
Direct costs for the year:  $100,000
Indirect costs for the year:  $49,177

PI:  William S. Weinstraub, MD (EUSOM)
Co-Investigator:  Andrzej Kosinski
Title:  The Economic Quality of Life and Cost-effectiveness substudy of the clinical outcomes utilizing revascularization and aggressive drug evaluation (COURAGE) trial
Funding Agency:  West Haven VA
Direct costs for the year:  $51,159
Indirect costs for the year:  $15,348

H. PRESENTATIONS AT PROFESSIONAL MEETINGS

Barnhart, Huiman X.  Models for multivariate random length data – joint modeling for data with two outcomes.  To be presented in an invited session,  August 1999, Joint Statistical Meeting, Baltimore, Maryland.

Barnhart, Huiman X.  Models for multivariate random length data – joint modeling for data with two outcomes. December 1998, International Biometrics Conference, Cape Town,  South Africa.

Brogan, Donna J., Maxine Denniston, Jonathan Liff, Elaine Flagg, Ralph Coates, Louise Brinton.  “Comparison of Random Digit Dialing (RDD) and Area Probability Sampling (APS) on Nonresponse and Within Household Noncoverage”.  To be presented by Brogan October 28-31, 1999 in Portland, OR at the International Conference on Survey Nonresponse. (refereed)

Brogan, Donna, Maxine Denniston, Jonathan Liff, Elaine Flagg, Ralph Coates, Louise Brinton.  "Sampling a Control Group in an Epidemiological Case-Control Study".  To be presented by Brogan August 24-26, 1999 in Southampton, UK at the meeting “Analysis of Survey Data: an International Conference”. (refereed)

Brogan, Donna.  “Methodological Issues in Surveys of Consumer Satisfaction with Health Insurance Plans”.  To be presented by Brogan September 22-24, 1999 in Edinburgh, Scotland at the 3rd International Conference of Association for Survey Computing with the theme “Leading Survey and Statistical Computing into the New Millennium”. (refereed)

Brogan, Donna.  “The Institute of Medicine (IOM) Report on Lesbian Health: Implications for Women’s Health Research and Survey Methodology Research”.  Presented by Brogan on May 5 at Centers for Disease Control and Prevention (CDC), Atlanta.

Brogan, Donna.  “The Institute of Medicine (IOM) Report on Lesbian Health: Implications for Survey Research Methodology”, to be presented by Brogan on August 9 in Baltimore at the annual meeting of the American Statistical Association.

Brogan, Donna.  “The Institute of Medicine (IOM) Report on Lesbian Health: Implications for Women’s Health Research and Survey Methodology Research”.  To be presented by Brogan on August 2 in Washington, DC at the CDC/NIH National Conference on Health Statistics, “Health in the New Millennium: Making Choices and Measuring Impact”.

Denniston, Maxine, Donna Brogan, Frank Baker, Joseph Dye & Danette Hahn.  “Survey Design Challenges in Sampling Recently Diagnosed Cancer Survivors”, to be presented by Denniston at the annual meeting of the American Statistical Association, Baltimore, MD, August 8, 1999.

Fleuridor, R.*, Fefferis, R., Mageed, R., Lyles, R., and Pirofski, L. ?Isotypic and Idiotypic Analysis of Sera from Individuals with and without Cryptococcal Meningitis?, Abstract # 13008, Presented at The 98th General Meeting of the American Society for Microbiology, Atlanta, GA, May, 1998.

Forrest B., Feingold, E. and Manatunga, A. K. (1999) Analysis of age of onset data in siblings with genes shared by identically by descent. ENAR 1999, Atlanta.Invited Presentation, March 1999.

Haber, M.  Estimation of direct and indirect effects of vaccination. International Biometric Conference, Cape Town (December 1998).

Haber, M., Ndikuyeze, A.  Estimating the fraction of cases prevented by vaccination in a measles outbreak in Chad.  International Conference on Pharmacoepidemiology, Berlin (August 1998).

Hall, HI, RJ Coates, R Uhler, LA Brinton, MD Gammon, N Potischman, Donna Brogan, KE Malone, CA Swanson.  “Stage of Breast Cancer in Relation to Body Mass and Breast Size”, presented by Hall at Conference on Chronic Disease, Atlanta, December, 1998.

Halloran, M. Elizabeth.  Estimating vaccine efficacy for susceptibility and infectiousness. Symposium on AIDS Research Collaboration, Emory and Mexico, Instituto Nacional de Salud P?blica, Cuernavaca, Mexico, January 18-19, 1999.

Halloran, M. Elizabeth.  Exchangeability in hierarchical models, Symposium on Model Selection and Empirical Bayes, University of Nebraska, March 24-26, 1999.

Halloran, M. Elizabeth.  Use of validation sets for exposure to infection and for outcomes in vaccine trials. International Biometrics Conference, Capetown, South Africa, December 13-18, 1998.

Hanfelt, John J.  Optimal multi-stage designs for a Phase II trial that permits one dose escalation.  Society for Clinical Trials annual meeting, Anaheim, CA, May  4, 1999.

Hertzberg, Vicki Stover, W. Scott Clark & Donna Brogan.  “Developing Pedagogical and Communication Skills in Graduate Students: The Emory University Biostatistics TATTO Program”, to be presented by Hertzberg early August in Baltimore at the annual meeting of the American Statistical Association.

Hudgens, M.G., Longini, I.M. and Halloran, M.E.: Estimating the HIV transmission probability in injecting drug users in Thailand.  Invited  paper, Spring Meeting of the Biometric Society (ENAR), Atlanta, March 1999.

Kosinski AS, Flanders WD. “Evaluation of a diagnostic test without gold standard.” Invited session on statistical issues in diagnostic tests. ENAR Biometrics meeting, March 1999. (Chair: G. Satten; other participants: A. Hadgu, M. Sullivan-Pepe; discussant: J. Hanley).

Kosinski AS.  “Accounting for Verification Bias.”  International Biometric Conference, Cape Town, December 1998.

Kutner, Nancy and Donna Brogan.  “Race, Socioeconomic Status and Risk of a Catastrophic Health Condition in Later Life: Chronic Renal Failure among Blacks and Whites in a Southern State”, to be presented by Kutner in August, 1999  in Chicago, IL, at the annual meeting of the American Sociological Association.  (refereed)

Kutner, Nancy, Danni Daniels and Donna Brogan.  “Early Mortality in an Incident Dialysis Patient Sample: QOL, Significance of Sleep Disturbance, Restless Legs and Depression”, presented by Kutner on October 27, 1998 at annual meeting of American Society of Nephrology, Philadelphia, PA.

Longini Jr. IM, Halloran ME, Nizam A, et. al. Estimate of the Efficacy of Live, Attenuated Influenza Vaccine from a Two-Year Multi-Center Vaccine Trial: Implications for Influenza Epidemic Control.  Submitted 1999.

Longini, I.M., Hudgens, M.G. and Elizabeth Halloran, M.E.: ?Estimation of vaccine efficacy for both susceptibility to infection and reduction in infectiousness for prophylactic HIV vaccines with partner augmentation,? Invited talk, The Quantitative Evaluation of HIV Prevention Programs, Societal Institute of the Mathematical Sciences Conference, Donaine de Divonne, France, July 6-8, 1998.

Longini, I.M., Kitayaporn, D., Vanichseni, S., Choopanya, K., Hudgens, M.G., Elizabeth Halloran, M.E., Mastro, T.D. and Mock, P.A.: ?Estimation of vaccine efficacy for prophylactic HIV vaccines from field trials in developing countries.? Poster, XII International Conference on AIDS, Geneva, Switzerland, July, 1998.

Longini, I.M.:  University of Mexico School of Public Health, Cuernavaca, Mexico and the CDC/Thailand Collaboration, Bangkok, Thailand

Lyles, R., Muñoz, A., Bazmi, H., Yamashita, T., Detels, R., Rinaldo, C., Phair, J., Margolick, J., Mellors, J.* ?Natural History of HIV-1 Viremia After Seroconversion in the Multicenter AIDS Cohort Study?, Oral Presentation at The 6th Conference on Retroviruses and Opportunistic Infections, Chicago, IL, February, 1999.

Lyles, R.H. and McFarlane, G*. ?Adjusting for Measurement Error in the Initial Level and Rate of Change of an Exposure Variable?, Oral Presentation at the Joint Statistical Meetings of ASA and Biometric Society, Dallas, TX, August, 1998.

Lyles, R.H.* and Xu, J. ?Classifying Individuals Based on Predictors of Random Effects?, Oral Presentation at the Joint Statistical Meetings of ASA and Biometric Society, Dallas, TX, August, 1998.

Lyles, R.H.*, Tang, A.M., Mellors, J., Margolick, J.B., Visscher, B.R., Phair, J.P., and Graham, N.M.H. ?HIV RNA, CD4+Cell Count, and Immune Activation Markers Predict HIV-Related Weight Loss Prior to AIDS in the Multicenter AIDS Cohort Study (MACS)?, Abstract # 32167, Oral Presentation at The 12th World AIDS Conference, Geneva, June-July, 1998.

Lyles, R.H.:  ?HIV RNA and CD4 Lymphocyte Count Relate Differently to the Occurrence of PCP, CMV, and MAC Disease?, Oral Presentation, The 5th Conference on Retroviruses and Opportunistic Infections, Chicago, IL, February, 1998.

Manatunga A., Hudgens M., Chen S. (1998)  A Correction Term For Sample Size Estimation in Cluster Randomized Studies With Varying Cluster Size, Cape Town, South Africa, December 1998

Manatunga A., Hudgens M., Chen S. (1998)  A Correction Term For Sample Size Estimation in Cluster Randomized Studies With Varying Cluster Size, Controlled Clinical Trials Meeting, Atlanta, GA, May 1998.

Muñoz A., Lyles, R.H.*, Margolick, J.B., Giorgi, J.V., Chen, Y., Phair, J.P., and Mellors, J.W. ?HIV-RNA and CD4+ Decline without Therapy: Reference Values to Gauge Effectiveness of Antiretrovirals?, Abstract # 12127, Poster Presentation at The 12th World AIDS Conference, Geneva, June-July, 1998.

Nizam, A.  US-Bangladesh Cholera Working Group.  Epidemiology and Ecology of Vibrio Cholerae in Bangladesh.  Presentation made at the US-Japan meetings in Japan, December 1998.

Price, D. L. and Manatunga A. K. (1999) Use of Univariate Frailty Models to Analyze Survival Data with Cure, Poster Presentation, January 1999, CDC/ATSDR Symposium on Statistical Methods, Atlanta, January 1999.

Sacktor, N.C.*, Lyles, R.H., McFarlane, G., Skolasky, R.L., Kleeberger, C., Becker, J.T., Cohen, B., Wesch, J., Miller, E.N., and McArthur, J.C. ?The Changing Incidence of HIV-1-Related Neurological Diseases: 1990-1997?, Poster Presentation at The 6th Conference on Retroviruses and Opportunistic Infections, Chicago, IL, February, 1999.

Sacktor, N.C.*, Lyles, R.H., McFarlane, G., Skolasky, R.L., Kleeberger, C., Becker, J.T., Cohen, B., Wesch, J.,
Miller, E.N., McArthur, J.C., and The Multicenter AIDS Cohort Study Investigators. ?HIV-1-Related Neurological Disease Incidence Changes in the Era of Highly Active Antiretroviral Therapy?, Poster Presentation at The 51st Meeting of The American Academy of Neurology, April, 1999.

Sacktor, N.C.*, Skolasky, R.L., Esposito, D., Lyles, R., McFarlane, G., Nance-Sproson, T., Selnes, O., and McArthur, J.C. ?Combination Therapy Including Protease Inhibitors Improves Psychomotor Speed Performance in HIV Infection?, Neurology, 1998, 50: A248-249, Presented at The 50th Meeting of the American Academy of Neurology, 1998.

Sacktor, N.C.*, Skolasky, R.L., Lyles, R.H., McFarlane, G., Anderson, D.E., Miller, E.N., Selnes, O.A., Becker, J.T., Wesch, J., and McArthur, J.C. ?Highly Active Antiretroviral Therapy (HAART) Improves Cognitive Impairment in HIV+ Homosexual Men?, J. Neurovirology, 1998, 4: 365, Abstract Presented at national meeting of neurovirologists, 1998.

Viswanathan, B. and Manatunga, A.K. (1999) Bivariate frailty survival models for estimating heritability in twin data. ENAR 1999, Atlanta, March 1999.

Viswanathan, B. and Manatunga, A.K. (1999) Bivariate frailty survival models for estimating heritability in twin data.  January 1999 CDC/ATSDR Symposium on Statistical Methods, Atlanta, January, 1999

Waller, L.A.  “Models for clustering”. Atelier de Formation No. 106: Statistical methods for analyzing geographic variations in health indicators.  Intitut national de la Sant? et de la Research  M?dicale  (INSERM).  April 12-14, 1999, Le V?sinet, France.

Waller, L.A.  “Tests for putative health hazard assessment”.  Symposium on Environmental Epidemiology, International Society for Clinical Biostatistics 19th Annual conference, August 24-28, 1998.  Dundee, Scotland.

Waller, L.A.  Workshop on Status and Trends in Spatial Analysis, National Center for Geographic Information and Analysis, Santa Barbara, California, 1998.

Waller, L.A. and Conlon, E.M.  “Data-based neighborhoods, geographic effects, and spatial smoothing of disease rates”'. ENAR Biometric Society Meetings, March 28-31, 1999.

Waller, L.A., and Best, N.  “Flexibility in Hierarchical Models of disease rates”, Joint Statistical Meetings, August 9-13, 1998, Dallas, TX.

Williamson J. M. and Manatunga A. K. (1999) Latent Variable Modeling for Interrater Agreement Data. ENAR 1999, Atlanta. Invited Presentation, March 1999.

Yao, B., Haber, M.  Statistical analysis of partnership data.  Joint Statistical Meetings, Dallas, TX (August 1998).

VI. NARRATIVE

This past academic year saw significant changes in the Department of Biostatistics. We lost Senior Associate Danni Daniels to CDC. We have added strong faculty and promoted others within.  Andrzej Kosinski was promoted to Associate Professor with tenure.  M. Elizabeth Halloran was promoted to Professor.  Lance Waller joined us August 1, 1998, from University of Minnesota as Associate Professor with tenure.  John Hanfelt joined us October 1, 1998, from Georgetown University as Assistant Professor.  Robert Lyles joined us January 1, 1999, from Johns Hopkins University as Assistant Professor.  Kristie Polk joined us July 1, 1999, as Associate from Henry Country High School. We also welcomed several staff:  Portia Griffin, Senior Research Project Coordinator; Thandeka Tutu-Gxashe, Research Project Coordinator; and Gwendolyn Syphoe, Database Administrator.  With these strategic hires, we are well positioned to continue towards our goal of building a top echelon department of biostatistics.

A. CONTRIBUTIONS TO VALUES PLATFORM OF THE UNIVERSITY

In addition to the promotions and appointments in the department described above, there were other indicators of achievement of academic excellence.  Professors Huiman Barnhart and Andrzej Kosinski both won NSF/American Statistical Association Travel Awards to attend the 52nd session of the International Biometrics Conference in Cape Town, South Africa, December, 1998.  Professor Donna Brogan served on the Institute of Medicine Lesbian Health Research Priorities Committee.  Professor Donna Brogan gave workshops on sample survey techniques and the use of SUDAAN in Atlanta, GA; College Park, MD; Alexandria, VA; Denver, Co; and Ann Arbor, MI.  Professor M. Elizabeth Halloran gave invited presentations in Cape Town, South Africa; Cuernavaca, Mexico; and the University of Nebraska.  Professor John Hanfelt gave an invited presentation at the Society for Clinical Trails meeting, Anaheim, CA.  Professor Ira Longini gave invited presentations in Geneva Switzerland; Donaine de Divonne, France; and Atlanta, GA; and seminars in Cuernavaca, Mexico; and Bangkok, Thailand.  Professor Lance Waller gave invited presentations in Dallas, TX; Dundee, Scotland; Santa Barbara, CA; Atlanta, GA; Le Vesinet, France; and seminars at University of South Carolina; University of Georgia; Emory University (two); and the Environmental Protection Agency Region IV offices.  MSPH student, Mark S. Stevens, was selected as The Charles C. Shepard Award winner for 1999.

With respect to striking a balance between teaching and research, this goal continues to be vexing one in this department.  Although the faculty comprises many strong teachers, the demands for self-funding of faculty salaries, often at levels exceeding 60%, coupled with the relatively low tuition revenues returned to the department, provide a strong disincentive for faculty to assume more prominent roles in education.
Nevertheless, the faculty are responsive to the doctoral students, and the synergy occurring between faculty advisors and students at the dissertation research stage is stimulating both our research productivity as well as the teaching program in the advanced (700 level) classes.

BIOS faculty continued to contribute to the life of the Emory community.  Although BIOS faculty are relatively young, they have played significant roles in several Emory and RSPH committees. Professor Michael Haber served on the University Research Committee as well as on the RSPH Admissions Committee.  Professor M. Elizabeth Halloran served on the RSPH Appointment, Promotion, and Tenure Committee.  Professor Vicki Hertzberg served on the university Electronic Research Administration Committee and on Faculty Council.  She also served on the RSPH Curriculum Committee and chaired the GSAS Executive Council.  Professor Amita Manatunga served on the RSPH Strategic Planning Committee.

Keeping pace with infrastructure needs is an important challenge for BIOS.  In 1998-99, BIOS faculty matched funds provided by RSPH for updating the RSPH computing environment. Yet, we cannot rest on this solution, as in two more years we will be faced with funding another major upgrade.  It will be important for the department to identify permanent sources of income (endowment?) from which to plan for such upgrades on a continual basis.

With our long-standing tradition of research in biomedical problems, collaborating with scientists in other disciplines, BIOS faculty research exemplifies interdisciplinary scholarship.  Roughly 55% of the peer-reviewed publications of BIOS faculty were in journals outside of the statistical sciences.  Many BIOS faculty collaborate with scientists in other departments in RSPH, the Woodruff Health Sciences Center, CDC, American Cancer Society, and elsewhere.  Yet, there remain obstacles to the continued success of these kinds of collaborative activities.  Indirect costs are not easily recovered to the department for collaborative activities on which BIOS faculty are not principal investigators.  The skills that BIOS faculty bring to these collaborations sometimes are recognized inadequately in terms of authorship on eventual publications.  In reviewing these kinds of activities for eventual promotion and tenure, the BIOS faculty themselves have had difficulty in identifying the appropriate weight of collaborations versus research more delineated in biostatistical science.  Given this difficulty, the appropriate incentive structure for these activities has yet to be defined adequately.

Many BIOS faculty have made significant contributions to the profession of statistical science on the national level.  Several BIOS faculty have provided referee service to statistical journals as well as service as statistical referees for medical journals.  Professor Donna Brogan served on the Institute of Medicine Committee on Lesbian Health Research.  She has also served as a statistical consultant to Prudential Center for Health Care Research, and American Cancer Society.  Professor M. Elizabeth Halloran has served several times on the NIH ad hoc Statistics Study Section, and chaired its meeting in February, 1999.  Professor Vicki Hertzberg served on the National Institute of Neurological Disorders and Stroke’s Neurosciences Review Committee-A.  Professor Amita Manatunga is chairing the Local Arrangements Committee for the International Biometrics Society-Eastern North American Region 1999 Spring Statistics Meetings in Atlanta.  Professor Lance Waller served as General Methodology Chair for the Joint Statistical Meetings 2000 Program committee and was Newsletter Editor for the American Statistical Association's Section on Statistics and the Environment.

B.  STRENGTHS AND WEAKNESSES

The Department of Biostatistics is recognized as a national and international leader in thee areas of infectious disease modeling and vaccine trial design.  Faculty expertise also covers such core areas as clinical trials methods, survival analysis, and survey sampling.  Research content areas that are not covered at RSPH compared to other Biostatistics departments include demographic statistics, latent variables and mixture models, and probability theory.

The applicant pool for the Ph.D. program continues to improve in both quality of students as well as quantity of applicants, a characteristic that is borne out among the matriculating students.  The applicant pool for the MSPH program appears to be diminishing, and the quality of its members is uneven.

Faculty continues to publish in high-quality journals, both in the statistical sciences as well as in the medical sciences.

With the departure of Professor Eleanor Feingold in 1997, the department’s expertise in statistical genetics sustained a major blow.  This setback will not be reversible for a few years, when administrative issues in the Department of Genetics in the School of Medicine are resolved.  With the departure of Professor Scott Clark in 1998, the ability of the department to provide statistical support services through the mechanism of the Biostatistical Consulting Center was curtailed. However, a search process was undertaken this year to recruit a faculty member to lead the BCC.

C. OBJECTIVES FOR 1999-00

The department’s mission continues to be one to establish itself as the recognized leader of biostatistical science in the Southeast, pursuing excellence in the four core responsibility areas of education, service, methodological research, and collaborative research.  In November, 1997, the department faculty held a half day planning retreat, in which six major goals for the next five years were developed.  These are as follows:

1. Pursue both methodological and collaborative research to advance the science of biostatistics and meet the needs of the university as a whole, respectively.  Specific objectives include evaluation of the current departmental performance standards, then subsequently aligning individual faculty performance expectation and rewards with departmental goals.

2. Focus scientific study in the current areas of international recognition (specifically infectious disease modeling and vaccine trial design), expand functional core areas (specifically clinical trial methods, survival analysis, and survey sampling) and pursue new opportunities (specifically in the areas of environmental statistics, imaging statistics, spatial statistics, and statistical computing).  Additional objectives include continued pursuit of clinical trial opportunities, and development of a process to evaluate internal and external research opportunities on an ongoing basis.

3. Enhance both the quality and size of the educational programs to ensure financial viability of the department and continued recognition as a nationally competitive academic program.  In addition to maintenance and continued improvement of the existing programs at the graduate and professional level, the department should evaluate opportunities for undergraduate teaching at Emory.  Another objective is to increase the number of post-doctoral fellowship positions each year, and to increase the number of training grants from 1 to 2.

4. Increase influence and visibility of the department both internally and externally through citizenship and service initiatives.  Specific objectives include action as leaders in the development of statistics at Emory, while also strengthening the statistical consulting center through the addition of equipment, and support for students and faculty.

5. Grow the size of the faculty in a focused method to meet the scientific, education, and service goals of the department.  Specifically the objectives are to increase the number of tenure-track/tenured faculty to 16 in targeted scientific areas to fulfill identified needs, while increasing the number of associate faculty and staff members as needed in targeted areas.  A further objective is to create and appoint an endowed chair in the faculty in Biostatistics.

6. Develop an intellectually creative environment and culture that fosters faculty professional growth and achieves the department’s goals.  Specific objectives include developing a mentoring program for junior faculty as well as establishing mechanisms to enhance communication.

In 1998-99, the department met goals in all areas above.  Lance Waller joined us in August, 1998, bringing his research expertise in environmental and spatial statistics.  John Hanfelt will joined us in fall, 1998, bringing his research expertise in generalized linear models.  Robert Lyles joined us in January, 1999, bringing his research expertise in measurement error. These appointments brought the tenure-track/tenured faculty ranks to 11.  In the coming year, we aspire to search for a new tenure track faculty to develop a research program in imaging statistics.  We will also search for faculty to continue collaboration in clinical trials.